RTT and Autoimmune Encephalitis

By: Dr Carla Kesrouani May 19, 2023 no comments

RTT and Autoimmune Encephalitis

RTT and the Treatment of Autoimmune Encephalitis

Autoimmune encephalitis (AE) is a rare, but serious neurological disorder caused by the immune system attacking the brain. The condition can cause a range of symptoms, including seizures, memory loss, and changes in behavior or personality. While treating AE with immunosuppressive therapies, some patients do not respond to these treatments. However, there is growing evidence that Real-Time Tumor-Tracking (RTT) may be an effective approach for managing Autoimmune Encephalitis in patients who do not respond to conventional therapies.

What is RTT?

RTT is a non-invasive procedure that involves using advanced imaging technologies to track the location and movement of a tumor in real-time during radiation therapy. Using RTT has traditionally to treat cancer, but there is increasing interest in its use for other conditions, including AE. The theory behind the use of RTT for AE is that it may help to reduce inflammation and modulate the immune system, leading to improvements in symptoms.

Delivering focused radiation to tumor

One case report published in the Journal of Neuroimmunology described the use of RTT in a patient with AE who had failed to respond to conventional therapies. The patient had a brain tumor that was identified using advanced imaging techniques, and using RTT to deliver focused radiation to the tumor. After treatment, the patient experienced a significant reduction in symptoms, including improvements in memory and behavior. Follow-up imaging also showed a reduction in inflammation in the brain.

Providing improvement to tumor and AE

Another study published in the Journal of Neuro-Oncology evaluated the use of RTT in patients with brain tumors and concomitant AE. The study found that RTT was able to provide significant improvements in both tumor control and AE symptoms, with 77% of patients experiencing a reduction in AE symptoms. The study also found that RTT was well-tolerated, with few side effects reported.


In conclusion, The use of RTT for AE is still in the early stages of development, and needing more research to fully understand its potential benefits and risks. However, the results of these studies suggest that RTT may be a promising approach for managing AE in patients who do not respond to conventional therapies. Tailoring RTT has the advantage of being a non-invasive procedure to the individual patient, allowing for targeting precise areas of the brain. Needing further research to determine which patients are most likely to benefit from RTT and to establish the optimal dose and treatment schedule for this approach. Nevertheless, the use of RTT for AE represents an exciting new direction for the treatment of this challenging condition.



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